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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
23.94
Human Site:
Y185
Identified Species:
43.89
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
Y185
P
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
Y181
P
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
Dog
Lupus familis
XP_546130
745
81496
Y181
P
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
Y177
P
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
Rat
Rattus norvegicus
Q5RJQ4
350
39301
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
Chicken
Gallus gallus
NP_001004767
756
82614
Y196
P
R
P
R
I
G
P
Y
T
F
V
Q
Q
H
L
Frog
Xenopus laevis
NP_001091195
710
78684
Y161
P
R
P
C
I
G
P
Y
T
F
V
Q
R
H
L
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
W153
E
P
D
W
K
L
R
W
L
Q
R
E
F
Y
T
Honey Bee
Apis mellifera
XP_395386
868
98678
S135
H
Q
W
R
N
A
S
S
W
V
Q
K
Q
M
L
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
Q127
L
E
R
A
P
V
R
Q
K
L
T
N
Y
N
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
H23
V
S
Q
G
R
Y
F
H
V
G
E
L
T
M
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
0
N.A.
0
100
86.6
0
N.A.
0
20
0
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
0
N.A.
0
100
93.3
0
N.A.
20
33.3
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
8
0
0
0
0
0
0
0
0
8
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
47
0
0
8
0
0
% F
% Gly:
0
0
0
8
0
47
0
0
0
8
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
8
0
0
0
0
0
47
0
% H
% Ile:
0
0
0
0
47
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
8
0
0
8
0
0
0
% K
% Leu:
8
0
0
0
0
8
0
0
8
8
0
8
0
0
54
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
8
0
8
0
% N
% Pro:
47
8
47
0
8
0
47
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
8
0
0
0
0
8
0
8
8
47
47
0
0
% Q
% Arg:
0
47
8
47
8
0
16
0
0
0
8
0
8
0
0
% R
% Ser:
0
8
0
0
0
0
8
8
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
47
0
8
0
8
0
16
% T
% Val:
8
0
0
0
0
8
0
0
8
8
47
0
0
0
0
% V
% Trp:
0
0
8
8
0
0
0
8
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
47
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _